OK, besides all the fun and games...
Understand 1 thing
Only the 1st column will make the optimizer decide what index to use
So, putting all the columns in an index, lets say from a phonebook table is useless, if the list of columns are phone_num, Last_name, first_name, ect
AND you were looking up by last name
it would NEVER use that index and would scan...it MIGHT scan the index depending on the number of columns in your select vs. the columns in the table, vs. the columns in the index
So you see....we need to know what the barrel of data is, and how you want to go after it
There's some exotic stuff like merry-go-round scans...but don't think about
The Index Intersection thing however might be beneficial
But you can do some reading
Understanding SQL Server Indexing
SQL Server Index Basics
General Tips on Optimizing SQL Server Indexes
SQL Server Indexes: The Basics - SQLTeam.com