If DB2 thinks it is advantageous to do so, it will read in "big-block" mode (usually at an extent level). This will happen if DB2 guesses that it needs all or most of the pages in the extent. As previously menitoned, DB2 may do prefetches of pages which may trigger the big-block reads.
Otherwise, DB2 will read in page mode.
Obviously, physical I/O at the operating system level is different than at the database level.