Hi,
please provide more info about your system. What is your operating system name/version. What is your DB2 Server edition and version (commands: db2level , db2licm -l). What programming language are you using (is it java)? What is your APP server name and version etc. More info more help can be provided.
Check if DB2 server is started. Execute "db2start" command in command line.
Hope this helps,
Grofaty