I don't think STMM implementation has to anything with how many instances are running on your server. If your server has sufficient capacity in terms of CPU, Memory, Hardware and it is supporting the existing multiple instances quite well without any Degradation in performance, then the STMM will not do any harm in terms of multiple-instance. STMM makes your life easy if they are properly set as Bufferpool-tuning, Application Group parameters Tuning etc are automatically being taken care of by DB2's Self tuning tool.