perumj1, since you are on the mainframe (z/os I assume), it also depends on how your system is set up.
If every user has a separate table space, you can drop the table space which will get rid of all dependent objects (tables, Indexes, etc.).
If every user has a separate database, you can drop the database which will get rid of all dependent objects (table spaces, tables, Indexes, etc.).
Note: One item that will not be dropped automatically is any Aliases. These have to be dropped separately. Additionally, any Plans or Packages will have to be freed to remove them from the system (they will only be invalidated if the dependent tables / indexes are dropped).