I am not clear about your requirement, but if you want to update a column with a value which depends on a given condition, you can try the next statement:
UPDATE TBL1 A SET A.COL1 =
( CASE WHEN A.C2 = ? AND A.C3 = ? AND A.C4 = ? THEN ?
WHEN A.C2 = ? AND A.C3 = ? AND A.C4 = ? THEN ?
ELSE ?
END )
WHERE ( A.C2 = ? AND A.C3 = ? AND A.C4 = ? ) OR
( A.C2 = ? AND A.C3 = ? AND A.C4 = ? ) OR
( A.C2 = ? AND A.C3 = ? AND A.C4 = ? )
good luck,
saludos, aloz.