Hi,
First do a runstats for all your tables. That is a must. Then go ahead and do a reorgchk for all tables and see if the tables need to be reorged.
Then go ahead and enable snapshot monitors and depending on the snapshot's determine where the system needs more resources. You can use the db2 configuration advisor as a base for the settings and then go ahead and customize them based on the snapshot reports.
Please specify your db2 version and os version with every post.
HTH
Nitin.