No need for macro (although it can be done). Select the entire worksheet (upper left corner), then go to Format > Cells > Protection (tab). Uncheck the box for "Locked". Then select just that cell, go to Format > Cells > Protection (tab). Check the box for "Locked". Click OK. Then protect the sheet Tools > Protection > Protect Sheet. If no password given, then it will be protected. You can change any other cell, just not that one.