Create a macro.----If the data you want to match is in – say column Q1.
This code will change the matching cell to red, but you can use calcs or anything else based on the TRUE or FALSE return
Range("Q1").Select
ActiveCell.FormulaR1C1 = _
"=IF(RC[-2]<>""whatever data you want to match"",RC[-1]="" whatever data you want to match "")"
Range("Q1").Select
Selection.Copy
Range("Q4:Q2000").Select
ActiveSheet.Paste
Range("Q:Q").Select
Selection.FormatConditions.Delete
Selection.FormatConditions.Add Type:=xlCellValue, Operator:=xlEqual, _
Formula1:="TRUE"
With Selection.FormatConditions(1).Font
.Bold = True
.Italic = True
.ColorIndex = 1
End With
With Selection.FormatConditions(1).Borders(xlLeft)
.LineStyle = xlContinuous
.Weight = xlThin
.ColorIndex = xlAutomatic
End With
With Selection.FormatConditions(1).Borders(xlRight)
.LineStyle = xlContinuous
.Weight = xlThin
.ColorIndex = xlAutomatic
End With
With Selection.FormatConditions(1).Borders(xlTop)
.LineStyle = xlContinuous
.Weight = xlThin
.ColorIndex = xlAutomatic
End With
With Selection.FormatConditions(1).Borders(xlBottom)
.LineStyle = xlContinuous
.Weight = xlThin
.ColorIndex = xlAutomatic
End With