What is the content/type of the file?
Is there any other way?
Can you break it into smaller pieces using some tool/script?
Can you feed it into a database and perform the conversion there (this is designed for large data volumes)?
Anyway, why you want to manually edit a file over hunderd megabytes? If you want a piece, your better of writing a simple tool/script to do that. If its specialized content, there is probably a better way.
If you need to strip the data to feed it into a database, you might be better of writing a tool/script for it yourself if there database doesn't provide enough support.
- Joris Dobbelsteen