If it is in a single table without foreign keys then this is very possible. If you start adding lots of foreign key constraints then you should look at making sure that the references tables are cached as much as possible so that the data is validated as quickly as possible before being inserted.
Will the remote applications be able to transmit quickly enough the data over the network? Are they single insert statements or can then be bundled up using INSERT INTO table (f1, f2, f3) VALUES (1,2,3),(4,5,6),.... This will help keep your network traffic down too.
If this still does not give you the performance you are looking for and referential integrity constraints is handle by the application then consider using ISAM tables instead of InnoDB.