Are we talking classic
VB or
VB.Net?
What version of MS SQL?
What are the requirements around security of the application etc?
Can we assume you are doing this as a windows app not a web app?
Your biggest problem would be to manage concurrent users. Basically you need to avoid having the changes from one user overwriting the changes from another user.
Are you competant with database design?
What sort of database are you referring to eg. order management, bug tracking? What size?
More info will get you more targeted answers.